Chemotherapy-Associated Supravenous Hyperpigmentation

Chemotherapy-associated supravenous hyperpigmentation.

Serpentine supravenous hyperpigmentation following cisplatin and pemetrexed chemotherapy.

E20 CUTIS WWW.CUTIS.COM To the Editor: Serpentine supravenous hyperpigmentation (SSH) is a rare phenomenon characterized by linear hyperpigmentation of the skin overlying veins secondary to intravenous antineoplastic therapy. The term was first suggested by Hrushesky1 in 1976 as an uncommon side effect of administering intravenous 5-fluorouracil (5-FU). Although 5-FU is the most frequent offend...

Serpentine supravenous hyperpigmentation

Serpentine supravenous hyperpigmentation is a peculiar cutaneous eruption that follows the path of vein after intravenous injection of the chemotherapeutic agent. The lesions gradually resolve spontaneously if administration of the offending agent is stopped through the affected limb. Drugs such as 5-fluorouracil, docetaxel, vinorelbine, hydroxychloroquine, fotemustine, and minocycline are impl...

Tongue hyperpigmentation associated with chemotherapy

W e demonstrate a new hyperpigmentation on the tongue of a 68-year-old female patient who was diagnosed with stage IIA infiltrating ductal carcinoma of the left breast who underwent modified radical mastectomy followed by a triple chemotherapy regimen which consisted of doxorubicin, docetaxel, and cyclophosphamide. The patient developed the tongue hyperpigmentation a few weeks after the initiat...

Paclitaxel-associated reticulate hyperpigmentation: Report and review of chemotherapy-induced reticulate hyperpigmentation

Drug-induced reticulate hyperpigmentation is uncommon. Including the patient described in this report, chemotherapy-associated reticulate hyperpigmentation has only been described in ten individuals. This paper describes the features of a woman with recurrent and metastatic breast cancer who developed paclitaxel-induced reticulate hyperpigmentation and reviews the characteristics of other oncol...